Meet Your New Dentist

Department of Biomedical and Diagnostic Sciences

University of Detroit Mercy School of Dentistry

1. DBS 8030: Microbiology and Immunology
2. DBS 8250: Clinical immunology and Microbiology
3. DBS 8270: Microbiology and Infectious diseases

4. Graduate Dental Students:(Course director)

DEN5140: Microbiology and Immunology

5. Advisor to undergraduate students in cariology research

Research direction to the graduate students in the Labrotatory of Drs. Nobuhiro Hanada and Hidenobu Senpuku at National Institute of Infectious Diseases under National Institute of Health, Japan.

Teaching assistant to the undergraduate students in the Department of Oral Microbiology

Advisor to undergraduate students in the Department of Periodontology and Orthodontics.

My research interest is in studies to fully understand the mechanisms involved in the induction of protective immunity against a variety of microbial pathogens through vaccination and in host-microbial interactions in inflammation using animal models as well as humans. The vaccine delivery systems to be studied are biodegradable and biocompatible microspheres and liposomes, which are being tested to determine their ability to induce protective immune responses against bacterial and viral pathogens, e.g., P. gingivalis, Haemophilus influenza, and Streptococcus mutans. I am interested in molecular genetics and immunopathology of host defense, immune responses under different pathological conditions, and assessment of the effects of microbial factors and cell cycle host factors on T cells, B cells DC and NK cells. Consequently, I am also interested in how these effects influence host inflammatory responses, signaling pathways and protective immunity. I am also interested in studying how microbial pathogens activate components of both innate and adaptive immune systems and how these processes regulate disease progression. Specifically, how the Toll-like receptors, NK cells, MHC, and other molecules are involved in the induction and modulation of cellular responses to bacteria and their associated virulence factors. The ability of TLRs to differentially activate cell-signaling pathways and their role in modulating pro-inflammatory and anti-inflammatory gene expression and mucosal vaccine immunology are of special interest.

1. To determine the immunogenicity of Saliva binding region (SBR) of Streptococcus mutans, a key oral pathogen of dental caries, for the development of an anti-caries vaccine in vivo.
2. To investigate the role of host IgA in protective immunity to dental caries pathogens, including Streptococcus mutans and Lactobacillus

• Mohammad Abdus Salam, Jannet Katz, Ping Zhang, George Hajishengallis, and Suzanne M. Michalek: Immunogenicity of Salmonella Vector Vaccines Expressing SBR of Streptococcus mutans Under the Control of a T7-nirB (Dual) Promoter System. Vaccine. 2006: 24:5003-15.
• Mohammad Abdus Salam, Ryoma Nakao, Hideo Yonezawa, HaruoWatanabe, and Hidenobu Senpuku. Human T Cell Responses to Oral Streptococci in Human PBMC-NOD-SCID Mice. Oral Microbiol Immunol. 2006: 21:169-76.
• Mohammad Abdus Salam, Khairul Matin, Naoko Matsumoto, Yuzo Tsuha, Nobuhiro Hanada and Hidenobu Senpuku. E2f1 mutation induces early onset of diabetes and Sjogren's syndrome in nonobese diabetic mice. J Immunol. 2004;173:4908-18.
• Mohammad Abdus Salam, Naoko Matsumoto, Khairul Matin, Yuzo Tsuha, Ryoma Nakao, Nobuhiro Hanada, and Hidenobu Senpuku. Establishment of an animal model for initial adhesion of oral streptococci using recombinant non-obese diabetic mice. Clin Diagn Lab Immunol. 2004. 11: 379-86.
• Yuzo Tsuha, Nobuhiro Hanada, Toshihiko Asano, Toshihito Abei, Sachiko Yamaguchi, Md Abdus Salam, Ryoma Nakao, Hiroaki Takeuchi, Norimasa kurosaki & hidenobu Senpuku. Role of peptide antigen for induction of inhibitory antibodies to Streptococcus mutans in human oral cavity. Clin Exp Immunol. 2004;137(2):393-401.
• Matsumoto N, Salam MA, Watanabe H, Amagasa T, Senpuku H. Role of gene E2f1 in susceptibility to bacterial adherence of oral streptococci to tooth surfaces in mice. Oral Microbiol Immunol. 2004 Aug;19(4):270-6.
• Mohammad Abdus Salam, Michiko Sato, Etsuro Hoshino. Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiology and Immunology. 2001; 45- 1: 29-37.
• Mohammad Abdus Salam, Hidenobu Senpuku, Yoshiaki Nomura, Khairul Matin, Hideo Miyazaki, N. Hanada. Isolation of opportunistic pathogens in dental plaque saliva and tonsil samples from elderly. Japanese Journal of Infectious Diseases. 2001; 54, 193-195.
• Khairul Matin, Hidenobu Senpuku Salam Md. Abdus, et al. Effects of Monoclonal antibodies in Streptococcus mutans attachment. Bacterial Adherence Research. 2000, 14: 16-20.
• Hidenobu Senpuku, Khairul Matin, Salam Md. Abdus, Isamu Kurauchi, Noda Akira, Takatoshi Murata, Hideo Miyazaki and Nobuhiro Hanada. Inhibitory effects of Monoclonal Antibodies against a Surface Protien Antigen in Real-time Adherence in Vitro and Recolonization in Vivo of Streptococcus mutants. Scand. J. Immun. 2001; 54: 109-116.
• Mohammad Abdus Salam, Hidenobu Senpuku, Tsuha Yuzo, Naoko Matsumoto, Nobuhiro Hanada Adhesion of Streptococcus mutans on the tooth surface in a small animal model. Bacterial Adherence & Biofilm. 2001. 15: 14-21.
• Khairul Matin, Md. Abdus Salam, Joynab Akther, Nobuhiro Hanada, Hidenobu Senpuku. Role of Stromal Cell derived factor-1 (SDF-1) in the development of autoimmune diseases in nonobese diabetic (NOD) mice. Immunology 2002 Oct; 107 (2): 222-2232.
• Hidenobu Senpuku, Toshihiko Asno, Khairul Matin, Mohammad Abdus Salam et al. Effects of human interleukin-18 and interleukin-12 treatment on human lymphocytes engraftment in NOD-scid mice. Immunology 2002 Oct; 107 (2): 232-242.
• Ryoma Nakao, Nobuhiro Hanada, Toshihiko Asano, Takashi Hara, Md. Abdus Salam, Khairul Matin et al. Oral Transmission of HIV-1 in NOD/SCID B2mnull Mice Reconstituted with human Peripheral Blood Leukocytes. Immunology. 2003;109 (2): 271-282
• Salam MA, Katz J, Michalek SM. Role of Toll-like receptors in host responses to a virulence antigen of Streptococcus mutans expressed by a recombinant, attenuated Salmonella vector vaccine. Vaccine. 2010 Jul 12;28(31):4928-36.

• Mohammad Abdus Salam, Oscar Pino, Jannet Katz, Ping Zhang, and Suzzane M. Michalek TLRs and Host Responses to Cloned SBR of Streptococcus mutans. University of Alabama at Birmingham, USA. AADR/ADEA/CADA Orlando 2006.
• Mohammad Abdus Salam, Jannet Katz, Noel K. Childers, and Suzanne M. Michalek. Role of TLRs in Responses to Salmonella and Expressed SBR. University of Alabama at Birmingham, USA. The IADR/AADR/CADR 85th General Session and Exhibition (March 21-24, 2007) New Orleans, LA
• Mohammad Abdus Salam, Ping Zhang , Jannet Katz, and Suzzane M. Michalek. 1009 Immunogenicity of Salmonella Vector Vaccines Expressing SBR of Streptococcus mutans University of Alabama at Birmingham, USA The IADR/AADR/CADR 83rd General Session (March 9-12, 2005) Baltimore, MD
• Mohammad Abdus Salam, Naoko Matsumoto, and Hidenpobu Senpuku. Initial Adhesion of Oral Streptococci in Recombinant Non-obese Diabetic Mice. National Institute of Infectious Diseases, Tokyo, Japan. IADR/AADR/CADR 82nd General Session (March 10-13, 2004) Honolulu, HI
• Mohammad Abdus Salam, Yuzo Tsuha, Ryoma Nakao, Naoko Matsumoto, Nobuhiro Hanada, and Hidenobu Senpuku. Human T Cell Responses to Oral Biofilms Bacteria in Humanized NOD/SCID Mice. J. Dent Res. 2003. 82: A313
• Mohammad Abdus Salam, Khairul Matin, Tsuha Yuzo, Naoko M Matsumoto, Nobuhiro Hanada and Hidenobu Senpuku. The loss of E2F-1 induces early onset of Diabetes or Sjögren’s Syndrome in Non-obese Diabtic (NOD) Mice. J. Dent Res. 2002. 81: A313.
• Mohammad Abdus Salam, Nobuhiro Hanada, Khairul Matin, Naoko Matsumoto, Yuzo Tsuha and Hidenobu Senpuku. Establishment of E2F-1 Deficient Non-obese Diabetic (NOD) Mouse Model for Oral Diseases. Jpn J. Oral Biol, 44 (5) 95 (407), Oct 2002.
• Mohammad Abdus Salam, Nobuhiro Hanada, Tsuha Yuzo, Naoko Matsumoto, Hidenobu Senpuku. Biofilms formation in a mouse model: a new animal model for Oral biofilms infections. Medical Biofilms. 2002; 52.
• Mohammad Abdus Salam, Sato Michiko, Nakazawa Futishu, Hoshino Etsuro. Eubacterium saphenum and the cytokine productions by gamma-delta T cells in mice. Niigata Dent. J. 29 (2): 89, 1999
• Mohammad Abdus Salam, Hidenobu Senpuku, Tsuha Yuzo, Naoko Matsumoto, Nobuhiro Hanada. Adhesion of Streptococcus mutans on tooth surface of a small animal model. Bacterial Adherence 2001, 15: 28.
• Mohammad Abdus Salam, Hidenobu Senpuku, Tsuha Yuzo, Naoko Matsumoto, Nobuhiro Hanada. Adhesion of Streptococcus mutans on tooth surface of a small animal model. Bacterial Adherence 2001, 15: 28.
• Mohammad Abdus Salam, Hassan Oueis, and Michael O’Regan: Salivary IgA Antibody in Protective Immunity to Dental Caries. IADR/AADR/CADR General Session and Exhibition (March 15-19, 2011), SanDiego, CA.
• Aaron Jacob Weisberger, Hassan Oueis, Michael O’Regan, Michael Gleason, and Mohammad Abdus Salam. Correlation between Salivary Lactobacilli and Dental Caries in Children. IADR/AADR/CADR General Session and Exhibition (March 15-19, 2011), SanDiego, CA.
• Hassan Oueis, Michael O’Regan, Michael Gleason, and Mohammad Abdus Salam. Salivary Mutans Streptococcus and Caries Prevalence in School-Aged Children. IADR/AADR/CADR General Session and Exhibition (March 15-19, 2011), SanDiego,

1. Preparation of biopsy and surgical specimens for H-E and Immunohistochemical staining (ABC method).
2. Histological identification of Dysplasia, Carcinoma in situ, tumor cell, Differentiation of tumor cell, Lymphatic-vascular invasion, Perineural invasion, Depth of the tumor, Lymph node metastasis.

1. CT, MRI for identification of tumor, recurrence of tumor, lymph node metastasis, distant metastasis, Bone Regeneration and destruction and pathology of bone diseases.

• T-test
• Fisher test
• Cox-regression model
• Logistic Regression test
• Kaplan –Meier method
• Stat view with ANOVA
• SPSS

• Yukari Hagiwara, Yuki I. Kawamura, Kosuke Kataoka, Bibi Rahima, Raymond J. Jackson, Katsuhiro Komase, Taeko Dohi, Prosper N. Boyaka, Yoshifumi Takeda, Hiroshi Kiyono, Jerry R. McGhee, and Kohtaro Fujihashi. A Second Generation of Double Mutant Cholera Toxin Adjuvants: Enhanced Immunity without Intracellular Trafficking1. Journal of Immunology, 2006, 177: 3045–3054

• Bibi Rahima, Susumu Shingaki, Masaki Nagata, and Chikara Saito. Prognostic Significance of perineural invasion in oral and oropharyngeal carcinoma. J. Oral Surg. Oral Med. Oral Pathol. 2004: 97 (4), 423-431.

• Bibi Rahima, Susumu Shingaki, Takayuki Nakazato, and Chikara Saito. Impact of perineural invasion on survival of patients with tongue carcinoma. Asian J Oral Maxillofac. Surg, 2003:15: 243-249.

• Susumu Shingaki, Masahito Takada, Keisuke Sasai, Rahima Bibi, Tadaharu Kobayashi, Tsutomu Nomura, and Chikara Saito. Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am. J. Surg. 2003: 185:278-284.

• Yoshiyuki Takata, Masahito Takada, Naoya Izumi, Kanae Niimi, Yukiko Ono, Hiroyuki kanoh, Bibi Rahima, Tadaharu Kobayshi, Susumu Shingaki, and Chikara Saito. Clinical Study on Treatment Outcome of 135 Oral Squamous Cell Carcinoma for Past 14 Years. Niigata Dent. J. 2002: 32:75-78.

• Bibi Rahima T. NOMURA, M. NAGATA, and S. SHINGAKI, Niigata University, Japan. Analysis for prognostic significance of perineural invasion in carcinomas of Oral cavity and oropharynx (Abstract). J Dent. Research. 2002: 82; 3923.

• Bibi Rahima, Susumu Shingaki, Yukiko Ono, Tsutomu Nomura, Masaki Nagata, Ritsuo Takagi, and Chikara Saito. Prognostic implications of perineural invasion in squamous cell carcinomas of oral cavity and oropharynx (Abstract). 2002. Niigata Dent. J.22: 78-79.

• K.C. CHEON, S.A. MOSER, J.F. WHIDDON, R.C. OSGOOD, S. MOMENI, B. RAHIMA, J.D. RUBY, and N.K. CHILDERS, Diversity and stability of mutans streptococci genotype in children. 2008, The IADR 86th General Session & Exhibition at Metro Toronto Convention.

• JARMAN, R. OSGOOD, C. HSU, B. RAHIMA, G. CUTTER, and N. CHILDERS. Plaque Streptococcus mutans Count Variability Using Two Collection Methods. The IADR/AADR/CADR 85th General Session and Exhibition (March 21-24, 2007).